Testing of an Antitumor Enzyme L-lysine-A-oxidase from Trichoderma Harzianum Rifai F-180

نویسندگان

  • I. P. Smirnova
  • O. M. Kuznetsova
  • V. I. Ivanova-Radkevich
چکیده

An enzyme L-lysine-A-oxidase has been obtained from Trichoderma harzianum Rifai F-180. The analysis of serum from CBA mice immunized five times with native L-lysine-A-oxidase intravenously, at a dose of 35 U/kg, showed that the preparation had virtually no effect on the immune response to Tdependent antigen. L-lysine-A-oxidase at a dose of 35 U/kg administered twice intradermally has no effect on the delayed-type hypersensitivity. Multiple, parenteral administration of the native enzyme at doses of 35 U/kg and 70 U/kg slow down the spontaneous migration of leukocytes.

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تاریخ انتشار 2014